Such an association between large-vessel stroke and COVID-19 in young patients requires further investigation. conditions by non-COVID-19 individuals has also been reported and attributed to issues about acquiring in-hospital illness. Innovative methods that leverage modern technologies to tackle the COVID-19 pandemic have been introduced, which include telemedicine, dissemination of educational material over social networking, smartphone apps for case tracking, and artificial intelligence for pandemic modelling, among others. This short article provides a comprehensive overview of the pathophysiology and cardiovascular implications of COVID-19, its impact on existing pathways of care, the part of modern systems to tackle the pandemic, and a proposal of novel management algorithms for the most common acute cardiac conditions. Rsum La maladie coronavirus L-Homocysteine thiolactone hydrochloride 2019 (COVID-19), cause par le SARS-CoV-2 (pour coronavirus du syndrome respiratoire aigu svre 2), est la pandmie du sicle; en mai 2020, on dnombrait quelque 3,5 thousands de cas et 250 000 dcs dans le monde. Bien L-Homocysteine thiolactone hydrochloride que les sympt?mes respiratoires dominent gnralement le tableau clinique, on sait maintenant que la COVID-19 peut aussi avoir de graves consquences sur le strategy cardiovasculaire, par exemple des lsions myocardiques, des myocardites, des syndromes coronariens aigus, des embolies pulmonaires, des incidents vasculaires crbraux, des arythmies, des insuffisances cardiaques et des chocs cardiogniques. Les manifestations cardiaques de la COVID-19 pourraient tre lies la activation adrnergique, linflammation gnralise et au syndrome de libration des cytokines causs par le SARS-CoV-2, linfection directe des cellules myocardiques et endothliales par le disease, lhypoxie provoque par linsuffisance respiratoire, un dsquilibre lectrolytique, une surcharge liquidienne et aux effets indsirables de certains mdicaments utiliss pour traiter les sympt?mes de la COVID-19. En for?ant lannulation des interventions non urgentes et en rduisant lefficacit des voies daccs aux soins durgence, la COVID-19 a profondment transform les soins usuels prodigus tous les individuals en cardiologie, quils aient Rabbit polyclonal to ZNF22 besoin de soins ambulatoires ou aigus. On a aussi observ une diminution de lutilisation de solutions de soins de sant pour des problmes aigus par les individuals non atteints de COVID-19, une scenario attribue la crainte de contracter le disease lh?pital. Des approches novatrices faisant appel aux systems modernes ont t mises en ?uvre pour pallier les restrictions imposes par la pandmie de COVID-19, entre autres : tlmdecine, diffusion de matriel ducatif dans les mdias sociaux, suivi des cas au moyen dapplications pour tlphone intelligent et modlisation de la pandmie elegance lintelligence artificielle. Les auteurs de cet article passent en revue les consquences de la COVID-19 sur les plans physiopathologique et cardiovasculaire, ses rpercussions sur les voies daccs aux soins actuelles et le r?le des systems modernes dans la lutte contre la pandmie, et proposent de nouveaux algorithmes de prise en charge des problmes de sant cardiaque aigus les in addition courants. The coronavirus disease 2019 (COVID-19) is definitely a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),1 which infected 3,524,429 individuals and was linked to 247,838 deaths worldwide as of May 4, 2020.2 SARS-CoV-2 infection is triggered by binding to angiotensin-converting enzyme-2 (ACE2), which is highly indicated in the nasopharynx and lungs, as well as with the cardiovascular system and gastrointestinal and genitourinary tracts. 3 Although respiratory symptoms usually dominate the medical demonstration of COVID-19, SARS-CoV-2 illness might also be responsible for a variety L-Homocysteine thiolactone hydrochloride of potentially severe cardiovascular manifestations, particularly in individuals with pre-existing cardiovascular conditions. 4, 5, 6 Indeed, subjects with cardiovascular diseases do suffer worse results when infected with SARS-CoV-2.5 Moreover, COVID-19 could have an indirect impact on the delivery of cardiovascular care and attention (both in individuals with and without COVID-19) by reducing the efficiency of existing pathways (eg, primary percutaneous coronary intervention [PCI] networks and intensive care and attention unit [ICU] bed availability)7 and through decreased use of health care services by individuals because of concern about acquiring in-hospital infection. This short article provides a comprehensive overview of the pathophysiology and cardiovascular implications of COVID-19, its impact on existing pathways of care, the part of modern systems to tackle the pandemic, and a proposal of novel management algorithms for the most common acute cardiac conditions. Data Interpretation and Methodological Biases We examined the published literature (including multiple search strategies in MEDLINE with PubMed interface) and critically assessed early reports on medRxiv (https://www.medrxiv.org/). An.